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This study compared PMS ascorbate
2022-05-16
This study compared PMS+ascorbate and t-BHP in terms of their effects on the volume-dependent parameters of normal human RBCs. Incubation with both oxidative systems resulted in the RBC density and osmotic resistance distribution shifts. Clotrimazole or Са2+ added into the medium, as well as high ex
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These data suggest that the
2022-05-16
These data suggest that the dehydration of the SSRBCs induced by RANTES might result of an activation of the Gardos channel mediated by the chemokine receptor DARC. However, direct evidence of Gardos channel activation by chemokines in Duffy-positive SSRBCs leading to cell dehydration has not been e
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Bile acids BAs are detergent like amphipathic
2022-05-16
Bile acids (BAs) are detergent-like amphipathic molecules synthesized from cholesterol in the liver, stored in the gallbladder, and released into the intestine after food intake in order to facilitate the jnk inhibitor of dietary lipids and liposoluble vitamins. BAs travel along the intestine and o
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br Materials and methods br Results br Discussion
2022-05-16
Materials and methods Results Discussion It is known that MAPKs and Akt signaling can regulate cell migration [[24], [25], [26]]. In this study we found that dTAT-WKYMVm stimulates ERK, p38 and Akt phosphorylation in naïve CD4 T cell (Fig. 3A). However their activation did not affect naïve
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Due to the presence of all FGFRs in
2022-05-16
Due to the presence of all FGFRs in the epithelium, there are several FGFs ligands that could be binding to these FGF receptors, namely FGFs 1–4, 8–10, 16 and 18–20. By evaluating the known roles of FGFs in epithelial-mesenchymal interactions and in bone development, this list can be reduced. For ex
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br Introduction For decades regulated apoptosis
2022-05-16
Introduction For decades, regulated apoptosis and unregulated, accidental necrosis have been considered as the two sole cell death routes in multicellular organisms. With the beginning of the 21st century a paradigm shift has been witnessed by researchers in the field with the recognition that ma
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Compounds and were evaluated for their pharmacokinetic prope
2022-05-16
Compounds and were evaluated for their pharmacokinetic properties in rats and the results are summarized in . Following intravenous (IV) administration, both compounds displayed low clearance (CL), short half-lives (t) and low volumes of distribution (V). When dosed orally as a solution, exposure wa
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Although epigenetic mechanisms are implicated in the pathoge
2022-05-16
Although epigenetic mechanisms are implicated in the pathogenesis of hematopoietic malignancies, little is known about the role of lysine-specific histone demethylases and whether manipulation of these enzymes can be translated into targeted therapies. KDM6A is the most frequently mutated histone de
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UM 171 Histamine functions as a key neurotransmitter in mult
2022-05-16
Histamine functions as a key neurotransmitter in multiple circuits to control various behaviors. In Drosophila photoreceptor, histamine is produced de novo by histidine decarboxylase (Burg et al., 1993); meanwhile, maintaining normal histamine content also depends on the histamine recycling pathway
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coelenterazine br Acknowledgments br Introduction Liver dise
2022-05-13
Acknowledgments Introduction Liver disease is one of the leading causes of death worldwide. Death from any type of acute or chronic liver injury results when sufficient healthy hepatic parenchyma cannot be regenerated to perform vital liver-specific functions. Although the regenerative capabil
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Substrate affinity and specificity can be enhanced by dockin
2022-05-13
Substrate affinity and specificity can be enhanced by docking interactions, in which regions distal to the site of S-Adenosylhomocysteine bind to grooves, pockets, or surfaces outside of the kinase catalytic cleft 1, 2, 5, 6. Like catalytic site interactions, docking interactions can involve recogn
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GPR belongs to the G
2022-05-13
GPR84 belongs to the G protein-coupled receptor family, and it was first identified from human peripheral blood neutrophils [,]. GPR84 is now considered to be a member of receptor for medium chain fatty Ramiprilat (MCFA) with carbon chain lengths of 9–14 []. GPR84 is mainly expressed in bone marrow
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Continuing studies of endocannabinoid ligands at GPR
2022-05-13
Continuing studies of endocannabinoid ligands at GPR55 reveal that virodhamine (O-arachidonylethanolamine) and AEA can act as a partial agonists at GPR55; at high micromolar concentrations can inhibit β-arrestin recruitment (Sharir et al., 2012). It is likely that there are allosteric as well as ort
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Introduction Non alcoholic hepatic steatosis is
2022-05-13
Introduction Non-alcoholic hepatic steatosis is characterized by the presence of steatosis in hepatocytes [1], which leads to the development of fatty liver [2]. It is strongly associated with obesity, insulin resistance, and type II diabetes [3]. They are major risk factors of non-alcoholic hepati
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br TGR agonists current developments and
2022-05-13
TGR5 agonists: current developments and future landscape The amphipathic nature of bile acids is crucial in aiding the digestion and Cefotaxime sodium salt of vitamins and fats. With the emerging roles of bile acids in the regulation of energy and glucose homeostasis through TGR5, the pharmaceut
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