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UM 171 Histamine functions as a key neurotransmitter in mult
2022-05-16
Histamine functions as a key neurotransmitter in multiple circuits to control various behaviors. In Drosophila photoreceptor, histamine is produced de novo by histidine decarboxylase (Burg et al., 1993); meanwhile, maintaining normal histamine content also depends on the histamine recycling pathway
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coelenterazine br Acknowledgments br Introduction Liver dise
2022-05-13
Acknowledgments Introduction Liver disease is one of the leading causes of death worldwide. Death from any type of acute or chronic liver injury results when sufficient healthy hepatic parenchyma cannot be regenerated to perform vital liver-specific functions. Although the regenerative capabil
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Substrate affinity and specificity can be enhanced by dockin
2022-05-13
Substrate affinity and specificity can be enhanced by docking interactions, in which regions distal to the site of S-Adenosylhomocysteine bind to grooves, pockets, or surfaces outside of the kinase catalytic cleft 1, 2, 5, 6. Like catalytic site interactions, docking interactions can involve recogn
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GPR belongs to the G
2022-05-13
GPR84 belongs to the G protein-coupled receptor family, and it was first identified from human peripheral blood neutrophils [,]. GPR84 is now considered to be a member of receptor for medium chain fatty Ramiprilat (MCFA) with carbon chain lengths of 9–14 []. GPR84 is mainly expressed in bone marrow
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Continuing studies of endocannabinoid ligands at GPR
2022-05-13
Continuing studies of endocannabinoid ligands at GPR55 reveal that virodhamine (O-arachidonylethanolamine) and AEA can act as a partial agonists at GPR55; at high micromolar concentrations can inhibit β-arrestin recruitment (Sharir et al., 2012). It is likely that there are allosteric as well as ort
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Introduction Non alcoholic hepatic steatosis is
2022-05-13
Introduction Non-alcoholic hepatic steatosis is characterized by the presence of steatosis in hepatocytes [1], which leads to the development of fatty liver [2]. It is strongly associated with obesity, insulin resistance, and type II diabetes [3]. They are major risk factors of non-alcoholic hepati
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br TGR agonists current developments and
2022-05-13
TGR5 agonists: current developments and future landscape The amphipathic nature of bile acids is crucial in aiding the digestion and Cefotaxime sodium salt of vitamins and fats. With the emerging roles of bile acids in the regulation of energy and glucose homeostasis through TGR5, the pharmaceut
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This study does have important limitations
2022-05-13
This study does have important limitations to consider. The utilization of a recombinant gp120 monomer (at a single concentration of 100 ng/ml) instead of live virus particles may limit the validity of our results. Moreover, extrapolation of an in vitro cell culture model to animals or humans cannot
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Ubiquitination of GlyRs subunit on plasma membrane has been
2022-05-13
Ubiquitination of GlyRs-α1 subunit on plasma membrane has been shown to initiate the receptor CFDA SE Cell Tracer Kit and subsequent degradation in lysosomes (Buttner et al., 2001). However, the specific E3 ligase responsible for GlyRs-α1 ubiquitination is largely unknown as yet. Also, the functiona
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Glutamate is a ubiquitous principal
2022-05-13
Glutamate is a ubiquitous principal excitatory neurotransmitter in the Sildenafil that plays a central role in a variety of brain functions (Delgado, 2013, Hawkins, 2009). Several studies reported that CSF glutamate was associated with mental illness, including major depressive disorder, anxious an
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br Materials and methods br Results br Discussion br Acknowl
2022-05-13
Materials and methods Results Discussion Acknowledgments Introduction As we move into an aging society, there has been a growing interest in neurological disorders [1]. Neurodegenerative diseases such as Parkinson’s disease (PD) and Alzheimer’s disease (AD) cause cognitive malfunction
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br Regulation of GCK by intrinsic conformational dynamics
2022-05-13
Regulation of GCK by intrinsic conformational dynamics GCK is a 465-residue, 52-kDa enzyme comprised of two domains, hereafter referred to as the large domain and the small domain, that are separated by a flexible hinge region. As with other proteins that adopt the hexokinase fold, substrates bin
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AD is an irreversible and progressive neurodegenerative
2022-05-12
AD is an irreversible and progressive neurodegenerative disease affecting the Tranilast Sodium mg which insidiously destroys memory, thinking skills and cognition. Originally described in 1906 by German physician Alois Alzheimer, AD is characterized by the presence of intraneuronal neurofibrillary
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br Acknowledgements We apologize to our distinguished collea
2022-05-12
Acknowledgements We apologize to our distinguished colleagues whose work has not been cited owing to space limitations. This work was funded by the Italian Association for Cancer Research (AIRC, Milan, Italy, IG 14732 to A.M.); Italian Ministry of University and Education (Finanziamenti per la Ri
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br FPRs regulate anti microbial responses The classic eviden
2022-05-12
FPRs regulate anti-microbial responses The classic evidence supporting FPR as an anti-microbial receptor is that bacteria are the major biological source of chemotactic formyl peptides, fMLF binds to FPR and fMLF activates chemotactic and anti-microbial responses in neutrophils 2., 3.. Recently,
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