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In advanced GIST patients where a course of
2019-04-24
In advanced GIST patients where a course of treatment of Imatinib is interrupted by disease progression, subsequent rechallenge with Imatinib restored tumor control in most patients. In the prospective BFR14 trial, 25 patients with disease progression after interruption of one year of treatment rest
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Introduction Multiple myeloma MM is the most frequent
2019-04-24
Introduction Multiple myeloma (MM) is the most frequent cancer to involve the skeleton with 80–90% of patients developing bone lesions during their disease course [1]. Myeloma bone lesions are purely osteolytic and are associated with severe and debilitating bone pain, pathologic fractures, hyperca
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A previous study from our
2019-04-24
A previous study from our group demonstrated that the truncated form of OPG (1-194) has greater activity than the complete form, given that proteoglycans present in the bone tumor microenvironment may bind to full length OPG, thereby limiting its bioavailability and bioactivity [31]. Therefore the t
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The animal model described here is also expected to
2019-04-24
The animal model described here is also expected to lead us to design mechanism-based therapeutic interventions for bone metastases of NB. In this context, it is notable that the selective COX-2 inhibitor NS-398, which is known to selectively inhibit COX-2 without affecting COX-1 activity [30], inhi
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En diversos lugares de M xico como en
2019-04-24
En diversos lugares de México, como en Guerrero, el Valle del Mezquital, la región de Actopan, etc., según confirman las publicaciones del Instituto Nacional de Antropología e Historia de la ciudad de México, la creencia de que los huesos de los antepasados se convierten en piedras con propiedades e
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Un peculiar texto de Borges enumera al
2019-04-24
Un peculiar texto de Borges enumera, al interior de su relato, interesantes ejemplos de varias categorías pertenecientes al idioma propuesto por John Wil-kins —un sabio inglés del siglo — cuyo objetivo fue diseñar un lenguaje mucho más completo, abarcador e incluso preciso, en sus descripciones del
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Understanding and defining these miRNA
2019-04-24
Understanding and defining these miRNA profiles helps to uncover the clinical usefulness of miRNAs. Numerous human clinical trials are currently evaluating miRNA therapeutics during various liver diseases, such as targeting miR-122 during chronic hepatitis C infection. Aside from therapeutics, the d
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Social determinants are the lived conditions
2019-04-24
Social determinants are the lived conditions (ie, social and economic) that influence wellbeing, and environmental influences on behaviour are those assessed with the health behaviour theory. Stages of change models (ie, those that recognise health behaviour as a series of progressive steps leading
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br Imagine providing care for low birthweight LBW lighter
2019-04-24
Imagine providing care for 900 000 low birthweight (LBW; lighter than 2500 g) newborn babies each year in sub-Saharan Africa—all attributable to preventable and treatable malaria. Many of these LBW babies will be born in rural and impoverished settings where access to health care is poorest and th
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rho inhibitor br In Anand Bhopal s discussion March of healt
2019-04-24
In Anand Bhopal\'s discussion (March, 2015) of health inequalities, social determinants of health, and advocacy for social change in health care in the 21st century, we were disappointed to see little recognition of the branch of medicine that rho inhibitor epitomises “societal doctors”: public h
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Introduction Osteosarcoma OS is the most common primary mali
2019-04-23
Introduction Osteosarcoma (OS) is the most common primary malignant tumor of the bone. This neoplasm is defined histologically by osteoid deposition by the malignant mesenchymal order DAPTinhibitor [1]. In OS, current evidence supports an osteoblastic population as the cell of origin [2], although
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Si en cada figura novelesca habitan en potencia tantas
2019-04-23
Si en cada figura novelesca habitan en potencia tantas identidades como lectores pueda tener, qué decir de un Rimbaud pictórico —la fórmula es de Cassou (1961b: 9)— que se nos ofrece rapsódicamente, descoyuntado, sin ensamblar. Un modelo para armar cuyo formato remite zip inhibitor otro de los instr
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Ante estas opiniones hay que
2019-04-23
Ante estas opiniones, hay que tomar en cuenta que: “investigaciones recientes muestran que los pueblos indígenas han emergido junto focal adhesion kinase procesos de revitalización étnica y cultural, que han transformado el escenario sociopolítico y han puesto en tela de juicio las antiguas conceptu
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Lastly it is equally important to mention that the
2019-04-23
Lastly, it is equally important to mention that the microenvironment and genetic background of the host with a previous history of two independent malignancies may have further facilitated the selective proliferation of a clone with trisomy 11 [9,10], while normal buy MK-0752 suffered proliferative
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Although a wealth of studies tracking
2019-04-23
Although a wealth of studies tracking ODA+ have been done, few have provided in-depth study of how ODA+ in reproductive, maternal, newborn, and child health affects health outcomes, and to what extent the long-term goal of donors has been achieved through aid programmes. This panel dataset opens the
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