Archives
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Significantly less is known about regulation of phytocystati
2020-08-08
Significantly less is known about regulation of phytocystatin gene expression. A genomic clone corresponding to the barley cystatin Icy gene has been characterized (Gaddour et al., 2001) and the function of its promoter region has been analysed by Martínez et al. (2005b). Bioinformatic analysis of t
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br Conclusion br Introduction The morphological variability
2020-08-08
Conclusion Introduction The morphological variability of aquatic plants is well documented, and in some cases has seriously constrained taxonomic resolution (Sculthorpe, 1967, Santamaría, 2002). Many of these variations are caused by the extensive phenotypic plasticity of aquatic plants, but t
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Etravirine Though limited to a large cohort
2020-08-08
Though limited to a large cohort of self-reported healthy individuals, associations between individual Etravirine have been identified which may be clinically significant. Though slight, there is a relationship between the CYP2D6-inferred metabolizer phenotype and the diplotype-predicted activities
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We have previously reported that CK is downregulated in sene
2020-08-08
We have previously reported that CK2 is downregulated in senescent human lung fibroblast IMR-90 cells, aged rat tissues, and aging nematodes [17,18]. CK2 downregulation induces cellular senescence via the PI3K-AKT-mTOR-reactive oxygen species-p53-p21Cip1/WAF1 pathway in human cells [[19], [20], [21]
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br Six Ankyrin Repeat Domain Containing ASB Proteins Asb
2020-08-08
Six-Ankyrin Repeat Domain-Containing ASB Proteins Asb family members contain a relatively divergent N-terminal domain, followed by a varying number of ankyrin repeats and a C-terminal SOCS box (Figure 3). Asb11 contains six ankyrin repeats, a feature that it shares with Asb5, Asb9, and Asb13, sug
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All known vertebrate TRIMs are categorized
2020-08-08
All known vertebrate TRIMs are categorized in 11 distinct subclasses depending on the types of domains present at their carboxyl-terminals (Fig. 3) [29], [35]. Beyond conserved N-terminal domains, it is the C-terminal that provides specificity of interactions with other proteins. The subclass IV for
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WES and validation by Sanger sequencing in PNGS revealed
2020-08-07
WES and validation by Sanger sequencing in PNGS-252 revealed an apparent homozygous c.4C>G missense alteration (GenBank: NM_014176.3), resulting in the amino CGP 57380 substitution p.Gln2Glu (Figure 1A). This mutation must be very rare, because this is not listed in the NHLBI Exome Sequencing Proje
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Of all ES cases approximately
2020-08-06
Of all ES cases, approximately 26–28% are metastatic diseases at diagnosis with the remainder being localized disease [14]. Instituting a systemic chemotherapy regimen in combination with surgery and/or radiotherapy has significantly increased the survival of patients with localized disease. The 5-y
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In the current study homozygosity
2020-08-06
In the current study homozygosity for the ACE I allele did not reveal any difference among patients and controls. While, interestingly homozygous D genotype was significantly different among cases and controls, the odds ratio 1.93 revealed D allele to increase the risk of development of psoriasis in
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br Conclusions Mulan is a mitochondrial E ubiquitin
2020-08-06
Conclusions Mulan is a mitochondrial E3 ubiquitin ligase with diverse roles in cell growth, cell death, and mitophagy. To better understand the mechanism of Mulan\'s function we used a modified yeast two-hybrid system to isolate proteins that interact with its cytoplasmic RING domain (amino acids
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br Conflict of interest br Author contributions br Acknowled
2020-08-06
Conflict of interest Author contributions Acknowledgments Introduction The repair pathway of DNA-DSBs through HR and the role of BRCA1 in repair kinetics by HR is also an important factor to unravel the radiation sensitization of novel small molecule inhibitors. The involvement of the br
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Ketorolac australia DHODH is the only enzyme in the pyrimidi
2020-08-06
DHODH is the only enzyme in the pyrimidine biosynthesis that is located in the mitochondria rather than the cytosol. Mitochondria are intracellular organelles that are mainly associated with the electron transport chain (ETC) and generation of cellular energy. Mitochondrial bioenergetics plays a sig
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We generate six versions for each benchmark which are
2020-08-06
We generate six versions for each benchmark, which are: Table 1 shows the comparison results of the time and memory overhead for each version of benchmark. Note that Vacquinol-1 synthesis the results of MM and FFT hardened by CFCSS are much lower than the results in the original paper because the
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For the first time we provide
2020-08-06
For the first time, we provide evidence for COMT Val158Met modulation of long-term fear extinction in humans, evident both in cortical (LPP) and autonomic (fear bradycardia) components of the conditioned fear response. We further found that the initial acquisition of fear is related to dispositional
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br Oxidoreductase like MEM for prodrug activation br Future
2020-08-06
Oxidoreductase-like MEM for prodrug activation Future outlook Although MEM-mediated prodrug activation has been performed by different MEMs and prodrugs, and their effectiveness have been proved in vivo, only a few types of MEMs or prodrugs have been explored in prodrug activation until now [2