• Artesunate: From Viability to Cell Death

  2026-09-07

  Artesunate research is often judged by a single viability value, yet that value may combine growth arrest and cell killing. This article presents a response-phenotyping framework that connects Artesunate mechanism, assay design, and more defensible interpretation in cancer models.

• SN-38 Disrupts FUBP1–FUSE DNA Binding

  2026-09-05

  The reference study identifies an additional activity of camptothecin and SN-38: inhibition of the interaction between the oncogenic transcriptional regulator FUBP1 and its single-stranded DNA target FUSE. By combining compound screening, AlphaScreen binding assays, and cellular gene-expression analysis, the authors connect topoisomerase I inhibitor pharmacology with transcriptional regulation in hepatocellular carcinoma.

• Amitriptyline HCl: Practical Lab Workflow

  2026-09-04

  Amitriptyline HCl (SKU B2231) provides a characterized small molecule for controlled neurotransmitter receptor modulation studies, with defined reference activities, solubility, purity, and storage conditions. It is suitable for exploratory neuropharmacology research when assay-specific controls are used, but it should not be treated as evidence of therapeutic efficacy, receptor selectivity, or performance in a particular disease model.

• GST-Driven Insecticide Resistance in M. usitatus

  2026-09-04

  The reference study identifies MuGSTs1 and GST-mediated antioxidant defense as important contributors to lambda-cyhalothrin resistance in Megalurothrips usitatus. Pharmacological GST inhibition with diethyl maleate reduced antioxidant capacity and markedly increased insecticide sensitivity, providing a mechanistic framework for resistance research and pest-management strategy design.

• GSK343: From EZH2 Mechanism to Translation

  2026-09-03

  A thought-leadership guide to using GSK343 as a selective EZH2 inhibitor for mechanistic epigenetic cancer research, with a translational framework connecting PRC2 biology, H3K27me3 control, and emerging APEX2–TERT findings.

• NP-40 Lysis Buffer for Neuroimmune Assays

  2026-09-03

  NP-40 Lysis Buffer can preserve native protein assemblies and phosphorylation states needed to interpret neuroimmune signaling. This guide develops an assay-selection framework linking extraction chemistry to FPR2/ALX, SYK-AKT, microglial, and NK-cell experiments.

• 7-Ethyl-10-hydroxycamptothecin Workflows

  2026-09-02

  Build more informative cancer assays with 7-Ethyl-10-hydroxycamptothecin, combining topoisomerase I inhibition, cell-cycle profiling, apoptosis measurements, and FUBP1–FUSE binding studies. This practical guide emphasizes fresh DMSO handling, time-resolved dosing, metastatic colon cancer models, and troubleshooting for reproducible advanced colon cancer research.

• DAPI Nuclear Stain Solution: Practical Protocol

  2026-09-02

  DAPI (4',6-Diamidino-2-Phenylindole) Nuclear Stain Solution, SKU K2402, provides a pre-diluted fluorescent DNA binding dye for nuclear visualization and endpoint assessment of membrane-compromised cells. It is suited to fixed-cell fluorescence microscopy and selected flow cytometry workflows, but its weak cell permeability limits routine staining of intact live cells.

• Obeticholic Acid: Designing Better FXR Assays

  2026-09-01

  Obeticholic Acid is a selective FXR agonist for mechanistic studies of bile acid homeostasis, cholestasis, and liver fibrosis. This article presents an assay-centered framework that connects FXR gene regulation with the Notch and NK-cell findings reported in recent fibrosis research without conflating distinct mechanisms.

• Central Control of Opioid Mechanical Hypersensitivity

  2026-08-31

  Yin et al. identify a brain-to-spinal opioid circuit that links repeated morphine exposure to mechanical hypersensitivity and analgesic tolerance in mice. The study separates mechanical pain adaptations from thermal effects and provides a circuit-level framework for opioid receptor signaling research and chronic pain research.

• Sodium-Driven Mitochondrial Failure in NECSO

  2026-08-31

  Qiao and colleagues show that TRPM4-mediated sodium influx drives NECSO by disrupting mitochondrial ion handling, oxidative phosphorylation, and the TCA cycle rather than acting only through plasma-membrane ion imbalance. The work establishes a mechanistic connection between sodium overload, ATP failure, Na/K-ATPase collapse, cellular swelling, and necrotic lysis, providing a framework for targeted mitochondrial function analysis.

• Human iPSC Sensory Neurons Model HSV-1 Latency

  2026-08-30

  Oh et al. developed and validated a scalable human iPSC-derived sensory neuron system that supports HSV-1 latency and experimentally induced reactivation. The model combines neuronal function with virological and chromatin-based latency criteria, providing a more human-relevant platform for studying neuron-intrinsic mechanisms and antiviral strategies.

• Toremifene in Breast Cancer: 20 Years of Evidence

  2026-08-29

  This review examines two decades of clinical and pharmacologic evidence for toremifene, a selective estrogen receptor modulator used in estrogen receptor-positive breast cancer. Its main contribution is to place efficacy, metabolism, tissue-selective effects, and safety in a personalized-treatment framework rather than presenting toremifene as uniformly superior to tamoxifen or aromatase inhibitors.

• 7-Ethyl-10-hydroxycamptothecin in Translation

  2026-08-28

  A translational framework for using 7-Ethyl-10-hydroxycamptothecin (SN-38) to connect topoisomerase I inhibition, replication-associated damage, apoptosis, cell-cycle control, and FUBP1 biology in advanced colon cancer research.

• Artesunate Workflows for Cancer Research

  2026-08-28

  Artesunate enables a more informative cancer-response workflow by separating growth suppression from actual cell killing. This guide translates its ferroptosis- and AKT/mTOR-relevant biology into practical dosing, time-course, assay-selection, and troubleshooting strategies for reproducible in vitro studies.

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