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In the normal BMD subgroup
2019-05-09
In the normal BMD subgroup, there was progressive bone loss over 3 years at the spine and hip (5.4% and 4.5%, respectively). This finding is consistent with the ATAC data [5]. Two patients required alendronate triggered by clinical events but there were no algorithm triggered events. There were no n
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br Mechanisms of arrhythmias Several schemes have been
2019-05-09
Mechanisms of arrhythmias Several schemes have been used to classify the mechanisms of cardiac arrhythmias. Traditionally, these have been divided into nonreentrant and reentrant activity [11]. An alternative scheme divided them into those occurring at the cellular and tissue levels [12]. A dynam
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In silico prediction software SIFT PolyPhen CADD
2019-05-09
In silico prediction software, SIFT [51], PolyPhen2 [52], CADD [53], and other prediction systems are useful to evaluate a specific mutation which is detected in a patient. However, even if the in silico software predicts a mutation as pathogenic, we need to examine whether the genetic result is com
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br Results The effect of BiV pacing
2019-05-09
Results The effect of BiV pacing and LV only pacing on hemodynamic responses is shown in Table 1. According to these results, no statistically significant differences in hemodynamic responses were seen in the two groups. Given that the end diastolic and systolic volume is different in men and wom
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br Introduction Bone marrow fibrosis is known to occur
2019-05-09
Introduction Bone marrow fibrosis is known to occur in several neoplastic and non-neoplastic conditions. Among neoplastic conditions such as acute leukemia, it is most often seen with acute megakaryoblastic leukemia [1]. Acute promyelocytic leukemia (APL) presenting with marrow fibrosis is a rare
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Friberg et al have indicated that the CHA DS
2019-05-09
Friberg et al. [17] have indicated that the CHA2DS2-VASc score is superior to the CHADS2 score in terms of stroke risk stratification, and the risk of stroke is extremely low among patients with a CHA2DS2-VASc score of 0 in whom antithrombotic therapy is not beneficial and may even increase the risk
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br Initially extrastimulation from the
2019-05-09
Initially, extrastimulation from the RV at a basic CL of 600ms showed no jump-up phenomenon and VA conduction block at a coupling interval of 480ms (not shown in the figure). The antegrade AVN conduction was evaluated by extrastimulation from the HRA and the ostium of the CS (CSp) at a basic CL of
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Hereditary syndromes with increased risk for gastric cancer
2019-05-09
Hereditary syndromes with increased risk for gastric cancer include: 1) hereditary diffuse gastric cancer, 2) Lynch syndrome/hereditary non-polyposis colorectal cancer, 3) juvenile polyposis syndrome, 4) Peutz-Jeghers syndrome and 5) familial adenomatous polyposis. Hereditary diffuse gastric cancer
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Heat shock facilitates the folding of
2019-05-09
Heat shock facilitates the folding of various proteins as mediated by the HSP family and can stabilize mutant proteins. HS has been reported to facilitate maturation of WT-HERG as well as mutant HERG by activating the HSF family [15]. HSF-1, 2, and 4 were reported to be expressed in humans. HSF-1 is
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The indications for epicardial mapping are
2019-05-08
The indications for epicardial mapping are institutionally variable but typically performed after a failed endocardial approach or if the etiology of cardiomyopathy suggests a high likelihood of epicardial scar (Fig. 9). Studies of patients with NICM that underwent combined epicardial–endocardial ap
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br Voltage gated sodium channels are essential
2019-05-08
Voltage-gated sodium Senexin B are essential for modulating the amplitude and upstroke velocity of the cardiac action potential, which are parameters that are important determinants of impulse propagation and conduction velocity through the myocardium. Functional analyses using patch-clamp techni
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By contrast the trials in
2019-05-08
By contrast, the trials in India show that if most of the target despite has no demand for sanitation then even a well-funded campaign will not succeed, and to study health effects will be pointless. The reasons for India\'s traditionally low demand for sanitation are complex, probably including cul
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MIP binds to three different
2019-05-07
MIP-1α binds to three different receptors: CCR1, CCR5 and CCR9. CCR1 and CCR5 are expressed on MM buy I-BET-762 and stromal cells. Inhibitors to CCR1 and CCR5 have been used to delineate the roles of each receptor in the myeloma bone marrow microenvironment[69]. Menu and colleagues demonstrated tha
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br Homing of DTCs to the HSC
2019-05-07
Homing of DTCs to the HSC niche The HSC niche is a complex microenvironment comprised of many cell types, including endothelial cells, adipocytes, osteoclasts, osteomacs, and chenodeoxycholic acid of osteoblastic lineage [5]. A healthy HSC niche provides homing signals to healthy HSCs in order t
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This patient had sick sinus syndrome and also
2019-05-07
This patient had sick-sinus syndrome and also took sotalol for the prevention of VT related to ARVC. Therefore, constant atrial pacing was indispensable for maintaining a physiological atrial rhythm. Frequent right ventricular pacing is known to cause left ventricular dysfunction, myocardial perfus
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