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br Results br Discussion In this
2019-08-13
Results Discussion In this study, we investigated the role of EP4 on invasion and invadopodia in breast cancer cells. Our results demonstrate that EP4 activation promotes invadopodia-driven ECM degradation, in turn facilitating future intravasation and metastasis of breast cancer clemastine (
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br Experimental Procedures br Author
2019-08-13
Experimental Procedures Author Contributions Acknowledgments Introduction Breast cancer is one of the most common malignancies for women worldwide, representing approximately 22% of women’s malignancies that pose a threat to women’s health [[1], [2], [3], [4]]. The morbidity rate of brea
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In addition to playing important roles in the immune
2019-08-13
In addition to playing important roles in the immune system, EBI2 is also expressed in the Deacetylase Inhibitor Cocktail in of the central nervous system (CNS), namely astrocytes, and this receptor regulates astrocyte signalling, as well as astrocyte cell migration (Rutkowska et al., 2015, Rutkows
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br Conclusion Our study demonstrates
2019-08-13
Conclusion Our study demonstrates that the effects of Epac activation are strongly conditioned by the steady-state Ca levels at which the myocyte is functioning. As intracellular Ca increases, the activity of CaMKII enhances and the phosphorylation of its SR substrates acquires different relevanc
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AZD 8055 Since OH PGE is a moderately selective EP
2019-08-13
Since 1-OH-PGE2 is a moderately selective EP4 agonist which could bind to mouse EP3 and EP4 with a relatively similar affinity (Kiriyama et al., 1997), we have used a highly selective EP4 agonist CAY10580 to evaluate the involvement of EP4 activation in PGE2-facilitated EP4 internalization and recyc
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Exposure to UV instead of DMBA also produced a
2019-08-13
Exposure to UV instead of DMBA also produced a sloughing and angiogenic response in transgenic, but not WT, mice, indicating that the epidermis of the BK5.EP4 mice has a much lower apoptosis threshold than WT mice, as suggested by others (Chun and Langenbach, 2007). Overall, these studies suggest th
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In order to assess quantitatively the contribution
2019-08-13
In order to assess quantitatively the contribution of the ung, dug and dut LY2109761 to uracil-DNA accumulation in E. coli, we have developed a novel method for measuring uracil residues in DNA that is based on the approach of Kow and co-workers [33] for measuring AP-sites in DNA. The method, which
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Hedamycin isolated from Streptomyces griseoruber belongs to
2019-08-12
Hedamycin, isolated from Streptomyces griseoruber, belongs to the highly cytotoxic pluramycin class of RG7388 (Figure 3(c)). It consists of a planar anthrapyrantrione chromophore attached to two amino sugar rings at one end and a bisepoxide-containing side-chain at the other end (Figure 3(c)). Heda
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br Experimental Procedures Further details and
2019-08-12
Experimental Procedures Further details and an outline of resources used in this work can be found in Supplemental Experimental Procedures. Introduction In response to T cell-dependent (TD) antigen stimulation, antigen-specific chemokine receptor migrate to the periphery of B cell follicles
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br Results br Discussion Analysis of EBI expression showed t
2019-08-12
Results Discussion Analysis of EBI2 expression showed that EBI2 is highly expressed in central memory CD8+ T cells that is in line with previous data from human T cells in which these Nutlin-3 express higher levels of EBI2 than naive or effector memory CD8+ T cells (Hannedouche et al., 2011).
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A key inciting event in atherosclerosis is
2019-08-12
A key inciting event in atherosclerosis is the deposition of circulating low-density lipoprotein (LDL) in the subendothelial space of major arteries. In the subendothelium, native LDL is no longer protected by circulating antioxidants and is oxidatively modified to oxidized LDL (OxLDL) [5]. OxLDL is
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br Materials and methods br Results br Discussion
2019-08-12
Materials and methods Results Discussion Chicken thrombocyte stimulation with LPS leads to a number of inflammatory responses through TLR4-linked pathways (Scott and Owens, 2008). In mammals, LPS binds to LPS-binding protein (LBP) in the blood serum and this complex is subsequently recogniz
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Sensory gating describes a filter mechanism protecting
2019-08-12
‘Sensory gating’ describes a filter mechanism protecting the central nervous system from sensory overload by inhibiting behaviorally irrelevant input (Boutros et al., 2004, 2008). This permits coelenterazine in to a changing contextual environment (Fruhstorfer et al., 1970; Grunwald et al., 2003). A
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The defining molecular feature of Ewing sarcoma is
2019-08-12
The defining molecular feature of Ewing sarcoma is the characteristic EWSR1/ETS fusion protein, most commonly involving EWSR1 and FLI1 (Delattre et al., 1992, May et al., 1993). EWS–FLI1 causes global changes in gene expression both by directly regulating gene expression and by causing changes in ch
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Herein we designed a strategy utilizing the target
2019-08-09
Herein, we designed a strategy utilizing the target-protection method to produce a signal in a system involving fluorescence CuNPs stabilized by dumbbell template DNA (DT DNA) through a locked circle consisting of two poly T loops and a poly (ATTA) stem. In the presence of MTase, DT DNA was modified
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