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Some family I DNA ligases
2019-08-17
Some family I DNA ligases can use dATP as nucleotide cofactor. For instance, human Psalmotoxin 1 I uses dATP with a catalytic efficiency that is only 36-fold lower in comparison to ATP [9]. EhDNAlig is unable to use dATP as a nucleotide cofactor, indicating a more constrained active site in comparis
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Steady state mRNA levels of
2019-08-17
Steady-state mRNA levels of CYP3A isoforms were not changed during liver insufficiency. Suppression of these isoforms was observed only at the protein and activity levels, suggesting a nongenomic mechanism of CYP3A isoform downregulation during liver insufficiency. Nonetheless, transcriptional activ
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Many investigators participated in the studies
2019-08-17
Many investigators participated in the studies on the regulation of the AZD6738 and experiments indicated that the process was conserved across many eukaryotic species including humans [127]. Because cancer cells exhibit dysregulated cell division along with the presence of abnormal chromosome numb
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br Phenotypic responses alkylation induced cell death and
2019-08-16
Phenotypic responses: alkylation-induced cell death and mutagenesis E. coli alkB mutants were isolated in a screen for strains specifically sensitive to the cytotoxicity of MMS but not UV-irradiation. This was the first indication that the AlkB protein is a primary cellular defence against alkyla
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N methyl d aspartate NMDA receptor antagonists such as MK
2019-08-16
N-methyl-d-aspartate (NMDA) receptor antagonists, such as MK-801 and phencyclidine, induce cognitive dysfunction in both mice and humans [18]. In addition, antipsychotic drugs ameliorate MK-801-induced cognitive dysfunction; therefore, the acute application of MK-801 can be used as an animal model o
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br Nuclear export and the functions of
2019-08-16
Nuclear export and the functions of CRM1 The nuclear envelope provides a compartmentalized intracellular environment for DNA replication, the synthesis of RNA, and production of ribosomes, and, as such, it can regulate cellular biological processes including apoptosis and proliferation. Nucleocyt
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motilin receptor The potential existence of ER stress was fi
2019-08-16
The potential existence of ER stress was first examined in EVTs in placental bed biopsy specimens obtained from pregnancies complicated by early-onset preeclampsia. It was then tested whether ER stress can modulate MMP-2 activity before elucidating the role of proinflammatory cytokines in the induct
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br Materials and Methods br
2019-08-16
Materials and Methods Acknowledgements Introduction The discoidin domain receptors, DDR1 and DDR2, are two closely related receptor tyrosine kinases (RTKs) that contain a discoidin (DS) homology domain in their extracellular regions. The DDRs were initially discovered by homology cloning ba
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Likewise the conserved cysteine in the E protein
2019-08-16
Likewise, the conserved cysteine in the E2 protein is the only residue shown to be essential for the transfer of Ub/Ubl from E2 to the HECT ligases (Dye and Schulman, 2007, Wu et al., 2003). However, all other terminal Ub/Ubl transfer reactions involving E2 enzymes suggest a critical role for the ta
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STRING protein interactions were used to highlight enzymes
2019-08-16
STRING protein interactions were used to highlight enzymes directly associated with DHODH (Fig. 10) (Szklarczyk et al., 2015). The reported protein-protein associations are primarily within the de novo nucleotide synthesis pathways (CAD, carbamoyl phosphate synthetase 1, uridine monophosphate synthe
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Polydatin Since anti MMP Therapy anti iNOS therapy TNF and I
2019-08-16
Since, anti-MMP Therapy [9], anti-iNOS therapy [10], TNF-α and IL-1β inhibitor (Diacerhein) [11] etc. are some of the disease modifying anti-osteoarthritis drugs have been used. But their action based on the evidence from the clinical trial and scientific literature suggesting the therapeutic effica
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The present study provides the
2019-08-16
The present study provides the first evidence that the human uroepithelial Cystamine dihydrochloride in vitro respond directly, within 48h, to this carcinogen by promoting extensive vacuolation and DAPK expression. By using the TEM, ICC and Western blotting, we found that the arsenite-induced vacuo
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Increased knowledge about CRC pathogenesis has provided new
2019-08-16
Increased knowledge about CRC pathogenesis has provided new and remarkable treatments beyond the classical options of surgery, radiation and chemotherapy [11]. Despite these advances, chemotherapy remains the most important element of anti-cancer therapy. Chemotherapy, when initiated, is generally e
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The anxiolytic like responses produced by anti SVG suggests
2019-08-16
The anxiolytic-like responses produced by anti-SVG-30 suggests that CRF2 receptors mediate not only the elicitation of anxiety behavior induced by prior stress, i.e. conditioned freezing, but also unconditioned anxiety behavior induced by exposure to the unfamiliar environment of the elevated plus m
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Under optimized assay conditions very low concentrations pM
2019-08-16
Under optimized assay conditions, very low concentrations (20pM) of [125I]YP20 bound to hCRF1-CHO TNF-alpha, recombinant rat protein membranes with high specificity (>95% inhibited by 1μM astressin) and in a membrane protein-dependent manner. Specific binding was selective vs. the hCRF2α subtype be
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