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nmda receptor antagonist Cell swelling stimulates the releas
2019-09-23
Cell swelling stimulates the release of certain amino acids, in particular the non-protein amino nmda receptor antagonist taurine, via a pathway which has the characteristics of a channel rather than a carrier [54], [69]. Indeed, on the basis of pharmacological inhibition, it was suggested that vol
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br Materials and methods br Results
2019-09-23
Materials and methods Results and discussion Conclusions Acknowledgments This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korean government (MEST) (No. 2011-0030635) and the MarineBio Research Program (NRF-C1ABA001-2011-0018561). The Fonta
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br Experimental br Results and discussion
2019-09-23
Experimental Results and discussion On the basis of the information obtained from the studies on RHA/TiO2 nanocomposites, it CA-074 is expected that this reagent can be used as a catalyst for the promotion of the organic reactions. So this reagent was used in the promotion of the conversion o
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Current therapeutic protocols in OS and ES consist of neoadj
2019-09-23
Current therapeutic protocols in OS and ES consist of neoadjuvant chemotherapy and local surgical resection, followed by adjuvant chemotherapy. These treatments lead to a 70% overall survival for localized disease but can decrease to 15% in case of metastasis. With CS being resistant to conventional
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The most common pathology associated with FGR is
2019-09-23
The most common pathology associated with FGR is poor placental perfusion as a result of abnormal placentation [4]. Placental developmental disorders and insufficient hormone synthesis may lead to FGR [5,6]. However, the exact mechanism responsible for abnormal placental development remains unclear.
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br Materials and methods br Results br
2019-09-23
Materials and methods Results Discussion Here we show expression of the EP1 receptor in the hippocampus of mice and the functional influence of the EP1 receptor on kainic pmsf molecular weight induced seizures. Mice lacking a functional EP1 receptor gene displayed a lower tendency to enter
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mechlorethamine Protein ubiquitination occurs at the lysine
2019-09-23
Protein ubiquitination occurs at the lysine residues, and is mediated by the sequential reactions of ubiquitin-activating enzyme (E1), conjugating enzyme (E2), and ligase (E3). The first step in this process comprises the ATP-dependent activation of ubiquitin by E1 to form a ubiquitin–E1 conjugate.
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The following are the supplementary data
2019-09-21
The following are the supplementary data related to this article. Acknowledgments Introduction Drug-resistant epilepsy (DRE) occurs in approximate 30% of patients who suffer from epilepsy [1]. Temporal lobe epilepsy (TLE) is one of the most common partial seizures and the common cause of DRE
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bromophenol blue clinical br Materials and methods br
2019-09-21
Materials and methods Results Discussion This study is the first to our knowledge that describes upstream cis-elements and transcription factors that are important for Crm1 expression and that drive its high expression in cancer and transformed cells. Using deletion and mutation analysis we
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The question remained as to why hCrm was
2019-09-21
The question remained as to why hCrm1 was functional and mCrm1 was not in terms of Rev and HIV mRNA nuclear export, and previously we proposed three possibilities (Elinav et al., 2012). One was that human ion channel had a positively acting factor that somehow stabilized the hCrm1 and Rev-RRE comple
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Stable isotope studies applied to skeletal remains of
2019-09-21
Stable isotope studies, applied to skeletal remains of early Pacific populations, have shown a trend toward a horticultural diet with temporal variation in response to local environmental conditions (Field et al., 2009; Kinaston and Buckley, 2013; Valentin et al., 2010, Valentin et al., 2014; Kinast
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GDC-0349 clinical SPR was used to measure biomolecular
2019-09-21
SPR was used to measure biomolecular kinetic interactions between TERRA G-quadruplex and ligand in the present study. SPR is a widely used method, but cannot tell which specific type of interaction happened. Compounds with similar structures probably have similar mechanism of interaction, while comp
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Apoptosis Inhibitor The anticholinesterase activities of all
2019-09-21
The anticholinesterase activities of all subfractions derived from EtOAc extract were detected and summarized in . Fraction 5 and its resulting subfractions (5B, 5C, 5D, 5C3, 5C4, 5D3, and 5D4) were found to show attractive activities. Subsequently, ten compounds (–) were obtained from these active
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br Author Contributions br Acknowledgments This work was
2019-09-21
Author Contributions Acknowledgments This work was supported, in part, by a grant from the National Cancer Institute of the National Institutes of Health under Grant U01CA202241 and National Institutes of Health under Grant R01NS083856. Introduction The Eph (erythropoietin-producing human
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KU14R kinase In contrast a single instillation of BLM result
2019-09-21
In contrast, a single instillation of BLM results in a progression of inflammatory events that culminates in marked remodeling of the lung interstitium. This process takes 2–3 weeks, with the fibrotic lesions becoming most pronounced within the first month [9]. Consequently, the BLM model offers th
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