• Recent studies show that the

  2020-04-02

  

  Recent studies show that the expression and function of some ion channels such as voltage-gated potassium channels, sodium channels and calcium channels are closely related to the proliferation, migration, and invasion of tumor cells [40], [41], [42]. Firstly, the expression of ion channels is chang

• br Molecular genetics Based on

  2020-04-02

  

  Molecular genetics Based on the genetic mutations associated with their development, sarcomas are subdivided into two distinct classes. One class is composed of tumors bearing complex karyotypic abnormalities with no particular pattern. The second class, which includes Ewing sarcoma, encompasses

• A recent analysis of urine samples collected from

  2020-04-02

  

  A recent analysis of 2721 urine samples collected from 245 men and 408 women across the US general population between 2005 and 2010 showed that MP, PP and BuP were measurable in 99.9%, 98.3% and 73.6% of samples from women and 99.3%, 90.2% and 35.9% of samples from men, respectively (Smith et al., 2

• Functional studies revealed that these ESR mutations lead

  2020-04-02

  

  Functional studies revealed that these ESR1 mutations lead to constitutive activity of the ER, meaning that the receptor is active in absence of estrogen, conferring resistance against several endocrine agents. Recent studies reported that the occurrence of ESR1 mutations is rare in ER+ primary brea

• br Materials and methods br Results br Discussion Cysteine p

  2020-04-01

  

  Materials and methods Results Discussion Cysteine proteases are upregulated under oxidative stress and play an important role in the preservation of cellular metabolism (Usui et al., 2007). Cysteine proteases are also important under abiotic stresses for plants to degrade proteins denatured

• The isolation of a proteinaceous putative inhibitor of

  2020-04-01

  

  The isolation of a proteinaceous putative inhibitor of cysteine proteases from the extracts of Y. enterocolitica and E. coli was performed by affinity chromatography on immobilized and inactivated papain (Fig. 7A). Instead of the column variant of this technique (Tsushima et al., 1992), we used a ba

• br Materials and methods br Results Metabolic stability of c

  2020-04-01

  

  Materials and methods Results Metabolic stability of compounds was studied by incubation with pooled human liver microsomes. Piperine was the metabolically most stable compound, with a t1/2 of 141min (Fig. 2, and Table 1). SCT-29 and LAU 397 showed t1/2 of approx. 45min, whereas a t1/2 of only

• Introduction Klebsiella pneumoniae a Gram negative

  2020-04-01

  

  Introduction Klebsiella pneumoniae, a Gram-negative enteric bacterium, is an organism with significance in both biomedicine and biotechnology. Some of the strains of K. pneumoniae are opportunistic pathogens, which can cause suppurative infection, pneumoniae and urinary tract infection in humans (B

• MoAbs targeting the tumourigenic pathways such as IGF R may

  2020-04-01

  

  MoAbs targeting the tumourigenic pathways, such as IGF-1R may theoretically have a dual working mechanism. On the one hand they block pathways having an anti-tumour working mechanism, and on the other hand they may also stimulate an immunological response inducing a reaction of the patients own immu

• L-Kynurenine mg br STAR Methods br Author Contributions br A

  2020-04-01

  

  STAR★Methods Author Contributions Acknowledgments The authors thank Monika Kuhn for excellent technical assistance and Dr. Antje Schäfer for valuable scientific input. H.S. was supported by the DFG (FZ 82; Graduate School of Life Sciences and SCHI 425-6/1), and A.V.S. by Northwestern Univer

• br Materials methods br Results and discussion The

  2020-04-01

  

  Materials & methods Results and discussion The comparison of BFI methods (Table 1) shows that Phosphatesmo failed to detect seminal fluid in all samples. This observation is concordant with other studies that investigated water-exposed seminal fluid stains [6], [7]. The Phosphatesmo test is us

• In contrast to G and

  2020-04-01

  

  In Ac-DEVD-pNA to G468 and G469, which are buried (Fig. 7a), residues 470–476 are equivalent to the surface loop L12 present in the crystal structure of the LigI complex (Fig. 7b) [17]. The OBD of DNA ligases adopts at least two distinct orientations during the catalytic cycle. In the adenylation s

• The two isoforms LDH A and LDH B catalyze

  2020-04-01

  

  The two isoforms LDH-A and LDH-B catalyze the same reaction, conversion of pyruvate to lactate at the end of glycolysis. LDH-A is expressed in the liver. Humans with a hereditary deficiency of the A or B LDH isoforms are free of symptoms, except for muscle rigidity and myoglobinuria following strenu

• Previous study showed that CXCR plays an important role

  2020-04-01

  

  Previous study showed that CXCR plays an important role in viral infection and that CXCR1, as an important molecule in CXCR, also plays important roles in viral pathogenesis [[39], [40], [41], [42]]. In mammals, CXCR1 plays an important role in resisting viral infection [43,44], and CXCR1 plays an i

• The oxidation of the lipid fraction of meat

  2020-04-01

  

  The oxidation of the lipid fraction of meat is an extremely complex process because of the high sensitivity of oxidation products to decomposition, their reactions with other components, the complex effect of catalysts and the presence of antioxidants. These changes are the main cause of limited she

16452 records 913/1097 page Previous Next First page 上5页 911912913914915 下5页 Last page