• When taken together data suggest CRF plays

  2021-12-30

  

  When taken together, data suggest CRF plays a central role in linking the HPA axis, the eCB system, and the amygdala with anxiety (Hill et al., 2009, 2010a; Hillard et al., 2011). In elaborate studies in mice, Gray and colleagues (Gray et al., 2015) showed stress-associated increase in CRF concentra

• Acknowledgments The authors would like to thank members of

  2021-12-30

  

  Acknowledgments The authors would like to thank members of the Department of Discovery Synthesis (DDS) and Biocon-Bristol Myers Squibb Research Center (BBRC) for scaling up key intermediates, analytical team for analytical experiments, lead profiling group for evaluating compounds in an in vitro AD

• Neochlorogenic acid In addition JMJ proteins respond to biot

  2021-12-30

  

  In addition, JMJ proteins respond to biotic stress and abiotic stress in plants. Rice genes OsJMJ704 and OsJMJ705, which have demethylase activities of H3K27me2/3 and H3K4me2/3, respectively, regulate defense-related genes and affect the defense ability of rice against bacterial pathogen Xoo (Li et

• Renal disease is characterized by aberrant fibrotic

  2021-12-30

  

  Renal disease is characterized by aberrant fibrotic remodeling of renal tissue, elevated apoptosis in kidney tissue, and eventual organ failure. In addition, patients with renal disease are more likely to suffer from systemic hypertension due to oxidative damage (reviewed in Ref. [18]). Treatment of

• br STAR Methods br Acknowledgments Anthony Koleske is thanke

  2021-12-30

  

  STAR★Methods Acknowledgments Anthony Koleske is thanked for helpful discussions and for providing p190RhoGAP-A cDNA. Anatoly Kiyatkin and Mark Lemmon are thanked for use of the BioTek Synergy 2 plate reader for the MANT assays. Leena Kuruvilla is thanked for assistance with the thermal shift a

• For several years CXCL had been classified as

  2021-12-30

  

  For several years, CXCL17 had been classified as an orphan chemokine, until Maravillas-Montero et al. claimed that orphan G-coupled protein receptor GPR35 is the receptor of CXCL17 [15], [16]. However, no following research has been produced to further explore the function of the CXCL17-CXCR8 (GPR3

• Further our study provides the

  2021-12-30

  

  Further, our study provides the first evidence that zaprinast and kynurenic Olomoucine administration not only prevented the development of thermal and mechanical hypersensitivity but also enhanced morphine antinociceptive properties. Morphine is considered to be one of the most effective analgesic

• Additionally OsGly I overexpressing transgenic rice plants h

  2021-12-30

  

  Additionally, OsGly I-overexpressing transgenic rice plants had higher grain yields than WT (Table 2). Although there were no significant differences in the number of effective panicles per plant, panicle length, grain numbers per panicle, or 1000-grain weight between WT and transgenic plants, the

• Much less is known about the and

  2021-12-30

  

  Much less is known about the α3 and α4 subunits. GlyR α3 subunit immunoreactive synapses are concentrated in discrete bands across the IPL; besides, bipolar, amacrine and ganglion cells have been suggested to express it (Haverkamp et al., 2003, Wässle et al., 2009). In fact, All amacrine express α3β

• br Contributions br Acknowledgements This

  2021-12-30

  

  Contributions Acknowledgements This research was supported by Natural Sciences and Engineering Research Council (NSERC) Discovery grant No. 341538 and Ontario Graduate Scholarships to HM and VS. Introduction Sexual size dimorphism describes size difference between male and female individua

• N Cadherin facilitated gap junction formation between

  2021-12-30

  

  N-Cadherin facilitated gap junction formation between embryonic lens WM-8014 by stabilizing membrane appositions (Frenzel and Johnson, 1996). Cx43 has been found to be delivered to N-Cadherin-positive membrane HeLa cells (Shaw et al., 2007), and N-Cadherin determine the localization of Cx43 in card

• uPAR promotes cell associated proteolysis

  2021-12-29

  

  uPAR promotes cell-associated proteolysis by binding to uPA which locally converts plasminogen into active plasmin [10]. Ligand-engaged uPAR also acts as a potent regulator of cell migration and matrix attachment. Being a membrane receptor, uPAR needs to interact with extracellular matrix (ECM) prot

• Our previous study had shown that silencing FFAR expression

  2021-12-29

  

  Our previous study had shown that silencing FFAR1 expression weakened the action of PIO in increasing insulin secretion in lipotoxic β Rifabutin [6]. Resent research found that PIO promoted insulin secretion by upregulating FFAR1 [17]. Therefore, we presumed that FFAR1 may be involved in the anti-l

• It is known that microglial function and morphology are clos

  2021-12-29

  

  It is known that microglial function and morphology are closely related [20], but no studies have addressed whether neuroinflammation induced by alcohol might modify microglial CORM-3 synthesis (i.e. morphology, neuroimmunochemical phenotype) through an eCB-dependent mechanism. Since this alcohol-i

• Accumulating evidence suggests an important role

  2021-12-29

  

  Accumulating evidence suggests an important role for endothelin ETB receptors in renal homeostasis. ETB receptors promote vasodilation, natriuresis, and diuresis (Davenport and Maguire, 2011) and maintain renal perfusion via counterbalancing the effects of vasoconstrictors and regulation of water re

16037 records 541/1070 page Previous Next First page 上5页 541542543544545 下5页 Last page