• While TUNEL staining is traditionally thought to be

  2022-09-01

  

  While TUNEL staining is traditionally thought to be an apoptosis marker, studies have shown that TUNEL can stain necrotic Pioglitazone receptor [19], [20], [21]. Furthermore, DNA degradation has also been observed in necrotic cells [22]. TUNEL staining alone is therefore insufficient to distinguish

• br Introduction Glucagon is a peptide hormone that

  2022-09-01

  

  Introduction Glucagon is a peptide hormone that acts to increase blood glucose levels. The secretion of glucagon from the alpha FUT-175 of the islets of Langerhans in the pancreas is increased during fasting and prevents hypoglycemia. Glucagon increases glycogenolysis and gluconeogenesis and the

• Piezo channels can be activated by

  2022-09-01

  

  Piezo channels can be activated by many mechanical stimuli . While some of these stimulations directly mimic physiological forces experienced by 57 9 synthesis , such as shear stress applied in a microfluidic chamber, the most commonly used modes of stimulation consist of stretching the membrane by

• In addition to inactivation of Notch we

  2022-09-01

  

  In addition to inactivation of Notch, we found that the combination of BTZ and GSI-I downregulated ERK phosphorylation in ALK+ ALCL cells, and we speculate this may occur through the inhibition of upstream regulators of the ERK pathway. These findings emphasize the functional complementation of the

• br The potential of EPA

  2022-09-01

  

  The potential of EPA-Ffar4 signaling as a novel intervention for HFpEF Conclusions and future directions Optimization of ω3-PUFA/EPA-therapy based upon titration to achieve therapeutic levels: A pressing clinical challenge is to continue to define the benefit of ω3-PUFA/EPA-therapy. Recent ana

• MC 1568 The G protein coupled receptor GPR also called

  2022-09-01

  

  The G protein-coupled receptor, GPR40 (also called FFAR1) responds to medium and long chain unsaturated fatty acids, resulting in increase of insulin secretion during elevated glucose levels. The glucose dependency of insulin secretion makes this receptor a very good target for developing therapies

• br FREE FATTY ACID RECEPTOR GPR br

  2022-09-01

  

  FREE FATTY ACID RECEPTOR 1 (GPR40) G-PROTEIN-COUPLED RECEPTOR 120 CONCLUSION Free fatty artesunate receptors whose natural ligands are identified as FFAs having various lengths have been reported. They act as novel nutrient sensing receptors independent of PPARs and FABPs, and they are kno

• Introduction High mobility group box HMGB is a nuclear

  2022-09-01

  

  Introduction High mobility group box 1 (HMGB1) is a nuclear protein that plays a fundamental role in the regulation of DNA-associated events such as DNA repair, transcription, and replication. HMGB1 can be translocated to the cytosol, plasma membrane, and extracellular space in response to various

• MK-8745 br Materials and methods br Results br

  2022-09-01

  

  Materials and methods Results Discussion This was the first large study to quantify both total HIV DNA and integrated HIV DNA, which is the main persistent form of HIV [25,26], in samples collected during PHI, chronic infection, and at various time points until the AIDS stage, which was mad

• 3'-Azido-3'-deoxythymidine β-D-glucuronide sodium sa

  2022-08-31

  

  Genome-wide binding and transcriptome analyses demonstrate that Fbxl10 directly binds the Areg, Mdk, Lmnb1, Thbs1, Mgp and Cxcl12 locus and thereby might influences the expression of these migration associated genes. The expression of epidermal growth factor (EGF)-like molecule Amphiregulin (Areg)

• In an effort to further improve the

  2022-08-31

  

  In an effort to further improve the intrinsic potency, we evaluated the effect of the C4-substituent of the triazole (). Replacement of the phenyl group with a cyclohexyl or with a 2-pyridyl substituent led to losses in potency. Increasing the size of the substituent to a bi-phenyl or naphthyl group

• Kinase Inhibitor Library synthesis Previous reports have imp

  2022-08-31

  

  Previous reports have implicated the guanylin/GC-C signalling system as being important in osmoregulation in fish, especially in euryhaline species such as the eel which migrate between freshwater (FW) and seawater (SW) environments at different stages of their life cycle (Comrie et al., 2001a, Comr

• GPR shares a amino acid sequence identity in humans

  2022-08-31

  

  GPR81 shares a 52% amino AS-1404 sequence identity in humans to GPR109A [1], [2], [3]. In addition, GPR81 is localized more specifically to the adipose tissue [3]. In 2008, lactate was discovered to be the endogenous ligand for GPR81 [9], [10]. Plasma lactate levels reach concentrations capable of

• Firstly the impact on activity and

  2022-08-30

  

  Firstly, the impact on activity and selectivity was made by replacing the 2, 3-di-F substitution of ring A with 2,3-OCHO- () and 2-NO () substitutions, and replacing the 3, 5-di-F substitution of ring B with 3,5-di-OMe () and 3,5-di-Me () substitutions. Compound kept moderate activity (EC = 220 nM)

• Autophagy as an important cellular process

  2022-08-30

  

  Autophagy as an important cellular process has drawn attentions to its role in cardiovascular systems [16]. Autophagy is a self-digestion and degradation process that recycles the contents of the cytosol, including macromolecules and cellular organelles, resulting in self-repair and conservation for

15338 records 356/1023 page Previous Next First page 上5页 356357358359360 下5页 Last page