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Reviewing the literature we knew that
2019-04-26
Reviewing the literature, we knew that in cases of AA, use of IST should be cautious, as IST might accelerate occult lymphoma escaping immune surveillance and evolving as a refractory lymphoma. Second, in cases of AA and concomitant NHL, to choose cytotoxic chemotherapy or IST is an art. Depending o
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Diversos trabajos coinciden en mencionar el impacto positivo
2019-04-25
Diversos trabajos coinciden en mencionar el impacto positivo que la auh ha tenido en términos de inclusión y justicia social frente UNC 0642 la situación donde sólo había asignación familiar contributiva, a partir de variables macroeconómicas como la modificación de tasas de pobreza e indigencia, un
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De esta manera el trabajo se centra en la
2019-04-25
De esta manera, el trabajo se centra en la discusión sobre las fronteras y territorios en el marco de la globalización y transnacionalización, la configuración de nuevos y viejos espacios simbólicos e identitarios, las interacciones y zonas de contacto existentes entre numerosos conjuntos sociocultu
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The measurement of the PPI
2019-04-25
The measurement of the PPI of DP following entrainment pacing usually consists of measuring the interval between the last capturing stimulus and the next DP. This technique is generally based on the assumption that, in the presence of 1:1 capture, pacing depolarizes the zone of slow conduction in th
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br Conflict of interest br Introduction Far
2019-04-25
Conflict of interest Introduction Far-field sensing of the atrial electrogram by a ventricular inhibited (VVI) pacemaker is a rare but potentially catastrophic phenomenon if there is no escape rhythm [1–3]. In this setting, the tip of the pacemaker lead is usually located in close proximity to
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br Conclusion br Conflict of interest br
2019-04-25
Conclusion Conflict of interest Introduction Recent trials of the use of implantable electronic devices, including implantable cardioverter defibrillators (ICDs) and cardiac resynchronization therapy defibrillators (CRT-Ds) show survival benefits [1–3]. As a result, implantable electronic d
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Cost effectiveness is another major concern for
2019-04-25
Cost effectiveness is another major concern for the governments in countries with public health system. Van-den Hout WB et al. at Netherlands [7] did a cost utility analysis showing the cost of radiation treatment including re-treatment for bone metastases using SF versus MF were €2438 versus €3311
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As with any open label study it
2019-04-25
As with any open-label study, it is possible that a placebo effect may have contributed to patients analgesia after initiation of the therapy. A randomized placebo-controlled trial would be required to finally prove the high analgesic effect of the loading-dose treatment with Ibandronate in metasta
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In addition evidence of similar
2019-04-25
In addition, evidence of similar resting HR׳s before exercise in the patients and in the controls implies similar autonomic activity at rest during the daytime in both groups of subjects. In contrast, previous studies have reported changes in the nocturnal HR of BrS patients [3,28]. The discrepancy
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At the mechanistic level our
2019-04-25
At the mechanistic level, our results strongly suggested that the cholestatic protective effect of STS was most likely accounted for by the activation of LXR, a nuclear receptor known for its anti-cholestatic activity. The activation of LXR was supported by the induction of typical LXR target genes,
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In summary programmed long AVD prolonged VA conduction time
2019-04-24
In summary, programmed long AVD, prolonged VA conduction time caused by anti-arrhythmic medication, and the rate of ELT (110bpm, below the upper tracking rate of 120bpm) were the reason ELT continued even in the presence of a programmed ELT termination algorithm. Physicians who manage patients with
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In advanced GIST patients where a course of
2019-04-24
In advanced GIST patients where a course of treatment of Imatinib is interrupted by disease progression, subsequent rechallenge with Imatinib restored tumor control in most patients. In the prospective BFR14 trial, 25 patients with disease progression after interruption of one year of treatment rest
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Introduction Multiple myeloma MM is the most frequent
2019-04-24
Introduction Multiple myeloma (MM) is the most frequent cancer to involve the skeleton with 80–90% of patients developing bone lesions during their disease course [1]. Myeloma bone lesions are purely osteolytic and are associated with severe and debilitating bone pain, pathologic fractures, hyperca
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A previous study from our
2019-04-24
A previous study from our group demonstrated that the truncated form of OPG (1-194) has greater activity than the complete form, given that proteoglycans present in the bone tumor microenvironment may bind to full length OPG, thereby limiting its bioavailability and bioactivity [31]. Therefore the t
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The animal model described here is also expected to
2019-04-24
The animal model described here is also expected to lead us to design mechanism-based therapeutic interventions for bone metastases of NB. In this context, it is notable that the selective COX-2 inhibitor NS-398, which is known to selectively inhibit COX-2 without affecting COX-1 activity [30], inhi
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