• Introduction Despite advances in breast cancer treatment bon

  2019-04-18

  

  Introduction Despite advances in breast cancer treatment, bone remains the most common site of Dorsomorphin Supplier [1,2] occurring in around 70% of patients with metastatic disease [3]. Bone metastases are incurable and associated with significant morbidity in terms of fractures, pain, and reduc

• In an effort to determine whether the

  2019-04-17

  

  In an effort to determine whether the primary tumour might be responsible for “fertilising” the bone “soil” ready for the cancer “seed”, we recently found that a hypoxic gene signature, and more specifically the secreted enzyme lysyl oxidase (LOX) was closely associated with bone metastasis, specifi

• The main inherited arrhythmogenic causes of SCD in the young

  2019-04-17

  

  The main inherited arrhythmogenic causes of SCD in the young are summarized in Fig. 1. These arrhythmogenic disorders include familial long QT syndrome (LQTS), catecholaminergic polymorphic ventricular tachycardia (CPVT), Brugada syndrome (BrS), idiopathic ventricular fibrillation, early repolarizat

• Para Galtung se evidencia que el concepto de violencia

  2019-04-17

  

  Para Galtung, se evidencia que el concepto de violencia tiene una triple dimensión: directa, estructural y cultural. Cuando surgen estas tres dimen siones se llama violencia line la afrenta evitable a las necesidades humanas. Así: En cuanto al marco teórico, se utilizan distintos enfoques para abor

• br INTRODUCCI N Con la

  2019-04-17

  

  INTRODUCCIÓN Con la incorporación de los derechos colectivos de los pueblos indígenas en la normatividad internacional de los derechos humanos, se inicia una nueva etapa en la conflictiva relación entre las bases fundacionales del poder político moderno y la diversidad cultural, en tanto aquellas

• In the management of BrS patients it is important

  2019-04-17

  

  In the management of BrS patients, it is important to avoid or treat certain drugs or circumstances such as a febrile state, electrolyte disturbances (hyperkalemia and hypercalcemia), and the use of class Ia/Ic antiarrhythmic drugs, vagotonic agents, beta-adrenergic antagonists, tricyclic antidepres

• In February a left neck

  2019-04-17

  

  In February 2013, a left neck infiltrating purpuric lesion around a previous surgical scar (lymph node biopsy) with mild pain was noted. A subsequent skin biopsy revealed metastatic adenocarcinoma, compatible with ampulla of Vater primary, thereby confirming disease progression with skin metastasis.

• The diagnosis is very difficult

  2019-04-17

  

  The diagnosis is very difficult on radiographical imaging alone as many tumours have similar radiological appearances to desmoplastic fibroma [2,7]. Biopsy is the gold standard method of determining the exact nature of any bony lesion as it provides a tissue diagnosis. The biopsy ideally should be p

• br Conflict of interest br Disclosures

  2019-04-17

  

  Conflict of interest Disclosures Acknowledgments Patient presentation A 64-year-old male with a history of a right ventricular outflow tract ventricular tachycardia (RVOT-VT) ablation presented from an outlying hospital due to four recent episodes of non-exertional syncope. He had three

• The principal difference between BrS and ERS

  2019-04-17

  

  The principal difference between BrS and ERS is related to the region of the ventricle most affected. Epicardial mapping studies in BrS patients report accentuated J waves and fragmented and/or late potentials in the epicardial region of the RVOT [129–131], whereas in ERS only accentuated J waves, p

• Given the recognized effects of bisphosphonates in metastati

  2019-04-16

  

  Given the recognized effects of bisphosphonates in metastatic breast cancer [14,15] and that potential anticancer effects have been demonstrated in preclinical [16], translational [17], patients with cancer therapy-induced bone loss [18] and GLPG0634 based-studies [19,20] a number of clinical trial

• La expansi n exportadora de Argentina hacia Colombia

  2019-04-16

  

  La expansión exportadora de Argentina hacia Colombia, Perú y Venezuela respondió rho kinase distintas razones, pero los mercados obviamente tuvieron mucho que ver. No fue casual que Colombia, por ejemplo, concentrara más de 65% de sus importaciones de Argentina en bienes primarios, pues la agricultu

• That well established data for

  2019-04-16

  

  That well-established data for Sapindaceae toxicity have long existed from clinical experience in Africa and the Caribbean is an important lesson for global health and neurotoxicology. A worldwide understanding of the adverse effects on the nervous system of both naturally occurring as well as synth

• The distribution of dental treatments

  2019-04-16

  

  The distribution of dental treatments and the number of treated teeth within each age group were also analyzed. The  6-years-old group had the lowest mean number of teeth treated by stainless-steel crown (SSC) and the lowest number undergoing pulp therapy (pstudy Angiogenesis Compound Library and,

• Introduction Osteosarcoma OS is the most

  2019-04-16

  

  Introduction Osteosarcoma (OS) is the most commonly diagnosed histological form of primary bone tumor with high morbidity, and it is mainly prevalent in teenagers and young people [1]. Pain is the most common early symptom of OS and can cause fracture of the affected bone. Currently, multiple thera

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