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br Acknowledgments Authors are thankful to the participants
2022-04-13
Acknowledgments Authors are thankful to the participants of the study for their cooperation. Financial support from Higher Education Commission (HEC) of Pakistan is highly acknowledged. AZ is supported by indigenous PhD fellowship from HEC. Indigenous PhD Fellowship for 5k Scholars batch 2 PIN NO
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br Material and methods br Results and discussion Unlike man
2022-04-12
Material and methods Results and discussion Unlike many fruits such as bananas and tomatoes, known as climacteric fruits, in which ripening is regulated by a burst of ap5 biosynthesis and an increase in respiration, pepper fruits, which do not follow this pattern, are called non-climacteric [
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The treatment target which aims at diagnosing of HIV
2022-04-12
The “90-90-90 treatment target” which aims at diagnosing 90% of HIV-infected individuals, treating 90% of those diagnosed and achieve viral suppression for 90% of treated individuals, is a key strategy to achieve one of the sustainable development goals (SDG) of ending AIDS as a public health threat
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amiodarone hcl br Specificity of CD T cells and their
2022-04-12
Specificity of CD4 T cells and their role in flavivirus neutralizing antibody responses CD4 T cells recognize peptides that are proteolytically processed from protein antigens and presented by MHC class II molecules on the surface of specialized antigen-presenting cells, such as dendritic cells o
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Experimental section br Results and discussion br
2022-04-12
Experimental section Results and discussion Conclusion In summary, we have developed a fluoresence method to sensitively detect hAAG on the basis of TdT-activated Endo IV-assisted hyperbranched amplification. This method shows the following advantages: (1) the combination of TdT-mediated exte
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br Results and discussion A diverse set of compounds were
2022-04-12
Results and discussion A diverse set of compounds were synthesized to improve the PK and physicochemical properties of 2. Compounds' agonist effects on hGPR40 were assessed by calcium mobilization assay using hGPR40-HEK293 cell line which stably expressed human GPR40. Preliminary explorations f
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br Acknowledgments This research was supported
2022-04-12
Acknowledgments This research was supported by a grant from the Korea Health Technology R&D Project through the Korean Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number: HI17C0616). Dr. Jun-Mo Yang was supported by the Natio
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Our data suggest that Slc a is important for
2022-04-12
Our data suggest that Slc38a5 is important for amino-acid-induced α cell proliferation and expansion of α cell mass following GCGR inhibition, but not for formation and maintenance of α cell mass. This is supported by the finding that Slc38a5−/− mice have normal α cell mass. This is interesting sinc
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Although in in vitro analyses GANT sensitized Daoy
2022-04-12
Although in in vitro analyses GANT61 sensitized Daoy nrf2 keap1 to RITA treatment, this was not fully reflected in the in vivo xenograft studies in nude mice, as the combinatorial treatment elicited a comparable reduction of tumor growth. However, the dual drug administration reduced within-group v
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Cetrorelix receptor Work in the Ruiz i Altaba lab was funded
2022-04-12
Work in the Ruiz i Altaba lab was funded by grants from the Swiss National Science Foundation, the Ligue Suisse Contre le Cancer, the European FP7 Marie-Curie Initial Training Network HEALING, a James McDonnell Foundation 21st Century Science Initiative in Brain Cancer-Research Award and funds from
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The sexual dimorphism in dlGALR a
2022-04-12
The sexual dimorphism in dlGALR1a and dlGALR1b receptors found in the gonads of adult fish led us to hypothesize that the gene expression difference between female and males might be attributed to the differences in steroid production between female and male gonads. Interestingly we have found that
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Based on this evidence future research should be directed to
2022-04-12
Based on this evidence, future research should be directed towards the identification of actual receptor oligomeric states at the analyzed cellular surfaces. The macromolecular organization of these oligomeric receptors might establish informational hubs, which relay ligand/receptor interactions in
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So what makes a FFAR agonist different
2022-04-12
So what makes a FFAR1 agonist different and interesting? As shown in the , the cellular mechanism is different from those of present insulin-releasing pharmacotherapies—namely the secretion initiators (sulphonylureas and meglitinides) and the incretin-based secretion potentiators (glucagon-like pept
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br Experimental procedures br Results br Discussion The data
2022-04-11
Experimental procedures Results Discussion The data herein confirm the well documented neuroinflammatory effect of TLR3 activation following systemic administration of the viral mimetic poly I:C and the associated acute sickness response which includes fever, reduced body weight and allodyn
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vadadustat br Materials and methods br Results br Discussion
2022-04-11
Materials and methods Results Discussion mmLDL is an important risk factor for cardiovascular disease, but its mechanism is still unclear. Previously, we co-cultured mmLDL with the coronary artery and basilar artery and found that mmLDL could upregulate ETB receptor expression in both [16],
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