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Free fatty acids FFAs which are obtained from dietary
2022-09-17
Free fatty acids (FFAs), which are obtained from dietary fat or endogenous synthesis, function as nutrients and signaling molecules. Studies have shown that free fatty Lck Inhibitor receptor receptors 1–4 which are G-protein coupled receptors, bind free fatty acids and serve as receptors for these F
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Methods br Results br Discussion SV exocytosis from
2022-09-17
Methods Results Discussion SV exocytosis from excitatory boutons is more sensitive to inhibition by isoflurane than exocytosis from inhibitory boutons,4, 31 but the mechanism(s) of this synaptic selectivity is unknown. Although P/Q-type VGCCs contributed quantitatively more to SV exocytosis t
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Introduction Vesicular exocytosis an intracellular
2022-09-17
Introduction Vesicular exocytosis, an intracellular membrane trafficking pathway, is a ubiquitous process for intercellular communication. It occurs when an intracellular vesicle fuses with the cell membrane and subsequently releases an infinitely minute number of chemical or biochemical messengers
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br Modulators of the GUCY C cGMP PDEs signaling pathways
2022-09-16
Modulators of the GUCY2C/cGMP/PDEs signaling pathways for CRC prevention and therapy (pre-clinical and clinical development) Several modulators of the GUCY2C/cGMP/PDEs signaling pathways, including GUCY2C agonists and PDEs inhibitors, have been developed and explored as chemopreventive agents for
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Previous studies have demonstrated that cannabinoid
2022-09-16
Previous studies have demonstrated that cannabinoid potentiation of GlyR α3 subunits contributes to cannabinoid-induced analgesia. For instance, Dehydroxylcannabidiol (DH-CBD), a chemically modified cannabinoid, can alleviate acute pain and chronic inflammatory pain by targeting spinal α3 GlyRs (Xio
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Na K ATPase adenosine triphosphate ATP and astrocytic glutam
2022-09-16
Na+/K+-ATPase, fda approved and astrocytic glutamate transporters act together to maintain sodium and potassium gradients and the proper activities of EAAT1 and EAAT2 (Rose et al., 2009; Sheean et al., 2013); nevertheless, in present study, Na+/K+-ATPase activity was shown to be increased as from 2
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br NLS and NES Mapping br Sequence Comparison of Gli
2022-09-16
NLS and NES Mapping Sequence Comparison of Gli NLSs—NLSs in ZF Domains Alignment of the Gli NLSs of representative metazoan animals suggests that the amino VKGILS-NH2 residues in the ZF domains are strongly conserved (Figure 4.2, Figure 4.3B). However, the length of the intervening amino acid
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A single ICV injection of GALP stimulated food intake
2022-09-15
A single ICV injection of GALP stimulated food intake in goldfish at 1h post-administration. This result is similar to that observed in rats, where ICV injection of GALP exerted an acute orexigenic effect [14], [15], [16]. Simultaneously, our findings counter the results found in mice, where central
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Tirofiban hydrochloride monohydrate WT associated protein WT
2022-09-15
WT1 associated protein (WTAP), a nuclear protein, is first identified by Little [6] who noticed its specific interaction with WT1. Besides several essential physiological processes, such as mRNA stabilization [7], eye development [8], m6A methylation [9], mRNA alternative splicing [10] and Tirofiban
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Loss of EZH function as a consequence of nonsense
2022-09-15
Loss of EZH2 function as a consequence of nonsense or frameshift mutations has also been detected in a cohort study conducted by Jankowska et al. in chronic myelomonocytic leukemia (CMML) patients, as an early event in cancer development [43]. Although, a recent study in Japan described increased le
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br Discussion In our study the prevalence of severe
2022-09-15
Discussion In our study the prevalence of severe periodontitis in patients with HIV infection was 66%, almost twice as high as in uninfected controls. Our results are in line with the prevalence of severe periodontitis found in HIV-infected patients in London, United Kingdom in the pre-cART era:
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In the present study we
2022-09-15
In the present study, we investigated the mechanisms underlying the ability of 5-FU to modify histone acetylation. Our results suggested that 5-FU induces global histone de-acetylation in CRC by promoting the degradation of p300 and CBP, two important homologous HATs catalyzing acetylation at multip
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br Dual acting HR antagonists While the present medicinal
2022-09-15
Dual-acting HR antagonists While the present medicinal chemistry efforts are mainly focused on selective ligands targeting GPCRs, and particularly on H1R, H3R and H4R selective antagonists/agonists, there were and, also, still are several efforts to develop dual acting H1R/H2R, H1R/H3R and H3R/H4
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In cancer cells HIF upregulates HK II expression by
2022-09-15
In cancer cells, HIF-1α upregulates HK-II expression by binding to the hypoxia-responsive element in the HK-II promoter region to adapt to hypoxic conditions [20]. In the present study, we observed that mangiferin transiently increased HIF-1α expression in endothelial cells, suggesting another possi
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Lastly haspin inhibitor was assessed against
2022-09-14
Lastly, haspin inhibitor was assessed against a panel of 292 kinases at 10μM. At this high concentration, the TKI258 inhibited thirteen kinases, in addition to haspin, ⩾90%., These kinases were CaMK2b, CaMK2d, CDK7-CycH-Mat1, cGK2, CK1d, CLK1, CLK2, DYRK1A, DYRK1B, DYRK3, PASK, PIM1 and PKD3. Int
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