• The androgen receptor gene AR

  2024-09-13

  

  The androgen receptor gene (AR) is located on the X-chromosome and consists of eight exons in humans (Brown et al., 1989; Kuiper et al., 1989). The similar gene structure in mice, monotremes and marsupials indicates AR is highly conserved in mammals (Choong et al., 1998; Faber et al., 1991; He et al

• In human epidermoid carcinoma A cells lipoxygenase was signi

  2024-09-13

  

  In human epidermoid carcinoma A431 cells, 12-lipoxygenase was significantly increased in glutathione-depleted cells. The relative abundance of phospholipid hydroperoxide versus glutathione peroxidase seems to play an important role in controlling the lipoxygenase reaction [57]. It has been proposed

• Adenosine is a ubiquitous homeostatic substance

  2024-09-12

  

  Adenosine is a ubiquitous homeostatic substance released from most cells, including neurons and glias. Endogenous adenosine acts at four principal G-protein-associated receptor subtypes: A1, A2a, A2b and A3 (Ralevic and Burnstock, 1998). The stimulation of adenosine receptors by extracellular adenos

• br Materials and methods br Results and discussion br Conclu

  2024-09-12

  

  Materials and methods Results and discussion Conclusion Amino-functionalized mesoporous TiO2-NH2 microparticles were used to immobilize ADA, followed by GLU cross-linking. The mesopores provided a natural microenvironment with sufficient room for the enzyme to efficiently perform its cataly

• To better understand the pathophysiology of ASDs

  2024-09-12

  

  To better understand the pathophysiology of ASDs, we would need comprehensive information on a) the functions of ASD-associated proteins in the brain, b) how mutations affect the expression level and function of these proteins, c) how mutations affect their function in neurons, and d) how changed ne

• Our initial approach to identify hits

  2024-09-12

  

  Our initial approach to identify hits was two-pronged and included a high-throughput screening (HTS) campaign of the OSI Superoxide Dismutase (SOD) Activity Assay Kit library as well as a virtual screening (VS) campaign, utilizing a publically available crystal structure of ACK1 (PDB code: ). A tol

• br Acknowledgements br Introduction Resistant

  2024-09-12

  

  Acknowledgements Introduction Resistant hypertension (RH), is defined as blood pressure (BP) > 140/90 mm Hg despite three full doses antihypertensive drugs including a diuretic. Controlled hypertensive patients taking four DL-AP5 Sodium salt or more of antihypertensives are also considered re

• br Disclosure br Acknowledgement br Introduction CYP

  2024-09-12

  

  Disclosure Acknowledgement Introduction CYP17A1 is a multifunctional enzyme with both 17α-hydroxylase and 17,20-lyase activities and is essential for the biosynthesis of steroidal ABT synthesis in male testes and adrenal glands. The 17α-hydroxylase activity of CYP17A1 is involved in the con

• We demonstrate a role for

  2024-09-12

  

  We demonstrate a role for low oxygen to regulate ATX mRNA in hepatocyte-derived HuH7 BAY 11-7082 and human liver slices, consistent with reports of increased ATX expression in a variety of tumours that are frequently hypoxic. Importantly, we show a positive association between elevated ATX mRNA lev

• Our results showed suppressed autophagy in GECs under HAGG s

  2024-09-12

  

  Our results showed suppressed autophagy in GECs under HAGG stimulation. Recently, people have paid more attentions on the roles of autophagy in lupus and tried to use autophagy regulators for therapy. Rapamycin could prevent the development of nephritis [49] and attenuate the established nephritis [

• Previously using a P lacZ reporter gene system it has

  2024-09-12

  

  Previously, using a P-lacZ reporter gene system, it has been shown that the β-galactosidase activity was 9-fold higher in the stationary phase beta-Nicotinamide mononucleotide when compared with those of the exponential phase [15]. Furthermore, inositol supplementation did not have a major effect on

• Human leukemic blasts from both AML and ALL patients

  2024-09-12

  

  Human leukemic blasts from both AML and ALL patients demonstrated 5-, 12-, and 15-LOX expression [54]; however, using quantitative PCR, 5-LOX was much more prevalent than 15-LOX. When 15-HETE, 12-HETE, and LTB4 were tested for a direct effect on leukemic blasts, none induced apoptosis [54]. In contr

• The results of our in vivo experiments provide

  2024-09-11

  

  The results of our in vivo experiments provide promising evidence that the apelin/APLNR axis is implicated in CCA growth and that targeting this axis with a receptor specific antagonist may help develop effective, tumor directed therapies. Not only do we show decreased proliferation and angiogenesis

• In conclusion our data highlight that variable anti oxidativ

  2024-09-11

  

  In conclusion, our data highlight that variable anti-oxidative NVP-BGJ398 phosphate could be released through peptic hydrolysis of CMP fractions. Although casein hydrolysates produced a larger number of peptides (Table 1) with variable antioxidant capacities, all the peptides from whey hydrolysate

• Of the cardiovascular studies involving ARBs reported

  2024-09-11

  

  Of the cardiovascular studies involving ARBs, 3 reported renal outcomes. In the Losartan Intervention For Endpoint study, albuminuria was observed less frequently in the losartan than in the atenolol arm (7% vs. 13%; p=0.002) (5). In the Candesartan Antihypertensive Survival Evaluation in Japan tria

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