• Irpex lacteus was well known as an edible

  2022-04-18

  

  Irpex lacteus was well known as an edible and medicinal mushroom. It had been reported that I. lacteus could produce a thermostable α-galactosidase [17]. The reported α-galactosidase from I. lacteus, however, seemed to be unsuitable for the practical application due to its poor hydrolysis ability to

• We have previously designed an azobenzene based molecule Raz

  2022-04-18

  

  We have previously designed an azobenzene-based molecule, Razo, which could switch the conformations of G-quadruplex structures by photoregulation. 12, 13, 14, 15 However, it lacks selectivity to different G-quadruplexes. Therefore, we want to find a way to modify this molecule so that it could be u

• Recently some researchers working in China Pharmaceutical

  2022-04-18

  

  Recently, some researchers working in China Pharmaceutical University developed novel FFA1 agonists some of which were found to be efficacious in the management of type 2 diabetes and with low toxicity. For instance, Zheng et al. [48] in their in vivo study using experimental animals, reported that

• In the present studies we found that genistein did

  2022-04-18

  

  In the present studies, we found that genistein did not antagonize fMLF-induced Ca2+ mobilization in FPR1-HL60 Evodiamine and human neutrophils. Thus, the previously reported inhibitory effect of genistein on fMLF-stimulated degranulation, aggregation, and reactive oxygen species (ROS) production i

• It has been reported that aberrant GPR expressions were

  2022-04-18

  

  It has been reported that aberrant GPR120 expressions were detected in colorectal carcinomas, compared with normal tissues. In addition, GPR120 stimulated cell motile activity and angiogenic property in colon cancer cells [10]. Recently, we indicated that GPR40 suppressed cell motile and invasive ac

• According to the implication of the endocannabinoid system

  2022-04-18

  

  According to the implication of the endocannabinoid system in IBD, we decided in our laboratory to develop selective CB agonists and FAAH inhibitors to treat these diseases. Recently, we described 3-carboxamido-5-aryl-isoxazoles as selective CB agonists. This series of isoxazoles possesses a 2-subst

• CTGF is an established YAP

  2022-04-16

  

  CTGF is an established YAP/TAZ target gene which plays a central role in tissue remodeling. Downregulation of CTGF mediates collagen loss in chronologically-aged human skin whereas persistent activation of CTGF can result in excessive deposition of collagen and fibrotic disorders [63]. The authors f

• br Materials and methods br Results br

  2022-04-16

  

  Materials and methods Results Discussion Numerous studies have identified important roles for HIF-1α in cellular function and dysfunction through its transcriptional activity [4]. A few studies have reported that HIF-1α is translocated to the mitochondria in human and mouse cancer cell line

• br Materials and methods br Results

  2022-04-16

  

  Materials and methods Results Discussion Dex has been shown to induce apoptosis in osteoblastic cell lines (MC3T3-E1, UAMS-32 cell) [24], [25]. Consistent with previous reports, we find high-dose Dex (1 or 5 μM) can induce apoptosis of MC3T3-E1 Medroxyprogesterone acetate within 24 h as ev

• Work is presently underway to unveil mechanisms whereby

  2022-04-16

  

  Work is presently underway to unveil mechanisms whereby SAHA-dependent restoration of cardiomyocyte autophagic flux is protective. Another interesting question pertains to mechanisms whereby class I and class II HDAC inhibitors induce autophagy. It has been demonstrated that TSA reduces transverse a

• Our study expands our current

  2022-04-16

  

  Our study expands our current knowledge of Ras-like small GTPase molecules involved in TLR-mediated responses in macrophages. We found that steady-state levels of Rap2a mRNA and protein undergo alterations after stimuli with TLR agonists. Although statistically significant, the effect of LPS-induced

• Here we show that CT recruits multiple Rab GTPases

  2022-04-16

  

  Here, we show that CT229 recruits multiple Rab GTPases and Rab effector proteins to the inclusion; the CT229 Inc protein redirects and intercepts host clathrin-coated vesicles (CCVs). CT229 is required for recruitment of transferrin (Tfn) positive CCV’s from the recycling pathway to the periphery of

• Migratory properties of Treg are

  2022-04-16

  

  Migratory properties of Treg are extremely important for the potential in vivo application. Therefore, the observed expression of CXCR3 on almost all obtained insulin-specific Treg is crucial for directing KW 3902 into the inflamed tissue (in this case pancreatic islets). CXCR3 responds to CXCL9, CX

• To further investigate its role in stresses tolerance OsGly

  2022-04-16

  

  To further investigate its role in stresses tolerance, OsGly I was overexpressed in transgenic rice. qRT-PCR and zymologic determination showed that CU CPT 4a level of OsGly I and the glyoxalase I activity were significantly increased to different extent in the transgenic overexpression lines (Fig.

• br Materials and methods br

  2022-04-16

  

  Materials and methods Results Discussion In this study, the supF forward mutation assay showed that 5OHU induced mutations in human cells and that a C→T mutation was the predominant mutation among 5OHU-induced mutations. In addition, the DNA cleavage activity assay revealed that 5OHU was ex

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