• br The lipoxygenase pathway in vascular physiology and patho

  2023-08-28

  

  The 12/15-lipoxygenase pathway in vascular physiology and pathology The mammalian 12- and 15-LOXs have high substrate specificity oxidizing predominantly ω−6 (arachidonic and linoleic acids) but also the ω−3 (docosahexanoic) dimethyl [86], [87], [88]. Different LOXs oxidize fatty acids both in t

• In this study we demonstrated that DRR protein

  2023-08-28

  

  In this study, we demonstrated that DRR1 protein level in GBM tissues was significantly higher compared to normal Capsaicin tissues. This data suggested that DRR1 might play a role in the tumorigenesis of glioma. To investigate whether DRR1 could accurately predict the outcome in patients with glio

• Polycyclic aromatic hydrocarbons PAHs are abundant

  2023-08-28

  

  Polycyclic aromatic hydrocarbons (PAHs) are abundant environmental contaminants that are produced by the incomplete combustion of organic matter, combustion engines, residential heating, CMK burning, and industrial activities (Gelboin, 1980; Phillips, 1999, Phillips, 2002). Some PAHs have been reco

• PC is considered as a cancer of the epigenome

  2023-08-26

  

  PC is considered as a cancer of the epigenome (Grasso et al., 2012, Robinson et al., 2015). Our results demonstrate that the interaction of AR with ACK1 drives the positive feedback epigenetic circuitry that is ultimately conducive to promote AR transcription. Further, this circuitry subjugates AR t

• br Acknowledgements br Introduction Resistant

  2023-08-26

  

  Acknowledgements Introduction Resistant hypertension (RH), is defined as blood pressure (BP) > 140/90 mm Hg despite three full doses antihypertensive drugs including a diuretic. Controlled hypertensive patients taking four lumacaftor or more of antihypertensives are also considered resistant

• geldanamycin br In patients with spina bifida and

  2023-08-26

  

  In patients with spina bifida and spinal cord injury, fecal incontinence is a serious issue that can impair activities of daily living and patient self-esteem. To address this Malone et al. first described the Antegrade Continence Enema (ACE) procedure in 1990 [1], which achieves continence by all

• Pompe disease is accompanied by the

  2023-08-26

  

  Pompe disease is accompanied by the deficiency of the lysosomal α-1,4-glucosidase that makes the cholinesterase inhibitors unable to hydrolyze glycogen to glucose, thereby resulting in the accumulation of glycogen in lysosomes, especially in skeletal muscles and cardiac tissues. This accumulation re

• Inactivation of autophagy can also impact the surface intern

  2023-08-26

  

  Inactivation of autophagy can also impact the surface internalization of MHC I molecules, leading to increased antigen presentation. Inactivation of autophagy factors Atg5 and Atg7 in DCs causes elevation of MHC I surface levels by decreasing endocytosis due to a poor recruitment of adaptor-associat

• CHK has been reported to

  2023-08-26

  

  CHK1 has been reported to be the kinase responsible for H3.3S31 phosphorylation in human ALT cancer GSK J4 . However, in our study, knockdown of CHK1 in HEK293F (Figs. S1c and S6) or HeLa S3 (data not shown) cells did not result in a significant decrease in H3.3S31ph, which is in agreement with an

• Recent studies have demonstrated that in response to IR

  2023-08-26

  

  Recent studies have demonstrated that in response to IR, hundreds of substrates are phosphorylated in an ATM-dependent manner, clearly demonstrating the complexity of the ATM-mediated DDR pathways (Matsuoka et al., 2007, Bennetzen et al., 2010, Bensimon et al., 2010). However, evidence suggesting th

• diltiazem hcl br Physiology of the apelin pathway br Role of

  2023-08-26

  

  Physiology of the apelin pathway Role of apelin in heart disease Both apelin and apelin receptor null mice manifested moderate reduction in cardiac contractile function under basal conditions and their exercise capacity was markedly reduced (Table 1) [56]. Apelin has direct effects on the prop

• Hypoxia of the adipose tissue is a key step in

  2023-08-26

  

  Hypoxia of the adipose tissue is a key step in the inflammatory response linked to obesity and contributes to accelerated tumor progression in the obese population (Rosenow et al., 2013). Intermittent hypoxia exposure induces a 2.2-fold increase in the infiltration of tumor-associated macrophages an

• The physiologic conditions and signaling mechanisms that reg

  2023-08-26

  

  The physiologic conditions and signaling mechanisms that regulate apelin secretion and APLNR expression in malignant tissues appear to be multifactorial. Previous studies have shown that hyperplastic and neoplastic cholangiocytes secrete a variety of hormones, peptides, and growth factors that help

• In summary our data have shown that one mechanism

  2023-08-26

  

  In summary, our data have shown that one mechanism by which glucose may mediate monocyte–endothelial cell interaction in the retinal endothelial cells is via the 12/15-LO pathway Furthermore, our current and previously published data [20,22] indicate a differential role of endothelial 12/15-LO versu

• br Discussion The present understanding is that patients suf

  2023-08-26

  

  Discussion The present understanding is that patients suffering from AD are at a higher risk for epilepsy than individuals without AD [[1], [2]]. The clinical diagnostic accuracy of AD has improved significantly during the last decades. However, most of the epidemiological studies on these two of

16088 records 296/1073 page Previous Next First page 上5页 296297298299300 下5页 Last page