• br Adenosine as a mediator

  2024-07-04

  

  Adenosine as a mediator of procedures used to manage pain The issue of caffeine Caffeine, from dietary sources, is perhaps the most widely consumed behaviorally active agent in the world (Fredholm et al., 1999). Initial characterization indicated caffeine had a higher affinity at A1−, A2A− and

• Adenosine is an endogenous nucleoside that plays pivotal

  2024-07-04

  

  Adenosine is an endogenous nucleoside that plays pivotal roles in different physiological and pathophysiological processes by triggering specific cell-surface receptors both in the 94 8 and in the periphery. The adenosine receptors (ARs) are four different subtypes of G protein-coupled receptors (G

• Salivary amylase activity was not

  2024-07-04

  

  Salivary α-amylase activity was not significantly different between bitches with pyometra and healthy bitches, and there were no significant changes after ovariohysterectomy, similar to chromogranin A (Jitpean et al., 2015). Therefore, it is postulated that the SAM axis is not activated in bitches w

• The first natural product described as

  2024-07-04

  

  The first natural product described as 5-LO inhibitor was the polyphenol nordihydroguaiaretic (+)-Catechin hydrate receptor from the Mexican dessert plant Larrea divaricata in 1981 (Bokoch and Reed, 1981), short after the initial identification of 5-LO in 1979 (Borgeat and Samuelsson, 1979). Long t

• Based on the observation that antipsychotic drugs increase H

  2024-07-04

  

  Based on the observation that antipsychotic drugs increase 5-HT1A–D2 heteromerization level (Łukasiewicz et al., 2016), we set out to compare the effect of paroxetine to that of risperidone. Paroxetine, a potent SSRI, is very effective in the treatment of depression and anxiety disorders, e.g., gene

• The first description of autophagy as a tumour suppression p

  2024-07-03

  

  The first description of autophagy as a tumour suppression process arises from the observation that the initial step regulatory gene, Atg6/BECN1, was monoallelically lost in 40% to 75% of human prostate, breast, and ovarian cancers [31]. However, while BECN1 heterozygous mutant mice develop, with lo

• Polyphenols like flavonoids have the potential

  2024-07-03

  

  Polyphenols like flavonoids have the potential to penetrate into lipid bilayers which is vital for enabling protection against oxidation. Rosmarinic SC-10 is a natural polyphenol antioxidant isolated from Sphaeranthus amaranthoides. Polyphenols can inhibit the propagation of lipid oxidation by two

• The acidification of endocytic compartments is

  2024-07-03

  

  The acidification of endocytic compartments is closely related to endocytic activity, although the mechanism linking acidification and membrane dynamics is largely unknown. In a recent RNA interference (RNAi)-based screen, V-ATPase depletion blocked the formation of clathrin-coated vesicles, an effe

• Introduction Lipoxygenases LOXs are key enzymes that catalyz

  2024-07-03

  

  Introduction Lipoxygenases (LOXs) are key enzymes that catalyze the polyunsaturated fatty acids (PUFAs) such as arachidic Safingol synthesis (AA), linoleic acid (LA) and others unsaturated fatty acids (Brash, 1999). LOXs are expressed in immune, neural, epithelial, tumor cells and other cells (Cla

• Of the many different types of

  2024-07-03

  

  Of the many different types of DNA lesions, DNA double strand breaks (DSBs) are amongst the most deleterious. It has been suggested that a single unrepaired DSB may be sufficient to induce cell death (Bennett et al., 1993), whereas misrepaired DSBs can result in loss of genetic information, potentia

• Molecular simulation has proven useful in describing the dyn

  2024-07-03

  

  Molecular simulation has proven useful in describing the dynamics and energetics of NMDA receptor LBD cleft closure and the potentiating role of glycans (Yao et al., 2013, Dai and Zhou, 2013, Dai and Zhou, 2015, Dai and Zhou, 2016, Dutta et al., 2015, Omotuyi and Ueda, 2015, Sinitskiy and Pande, 201

• To elucidate whether membrane fluidity

  2024-07-03

  

  To elucidate whether membrane fluidity changes could impact on signaling pathways, we examined the effects of Rh2 on the activation of Akt, a lipid raft-associated protein kinase, which promotes cell survival and blocks the apoptotic pathways. Upon pretreatment with 5 mM MβCD and in the absence of R

• br Conclusion We have identified three non competitive inhib

  2024-07-03

  

  Conclusion We have identified three non-competitive inhibitors of the human and porcine APN with Ki values in the μM range, by combining virtual screening and kinetic assays. Molecular docking simulations suggest these novel inhibitors block APN activity by an alternative mechanism to Zn coordina

• In the present study AP B preferentially released hydrophobi

  2024-07-03

  

  In the present study, AP31-B preferentially released hydrophobic Cy5 TSA mg such as leucine and alanine from N-terminal of peptide (Fig. 4). The debittering ability of AP31-B seemed to depend on such substrate specificity, but additional tests against other hydrophobic amino acids are needed to con

• br Discussion Here we focused on seven

  2024-07-02

  

  Discussion Here, we focused on seven plant alkaloids extracted from yokukansan. These alkaloids individually inhibited 5-HT-mediated 5-HT3A and 5-HT3AB receptor currents weakly. Simultaneous administration of these alkaloids, however, inhibited the 5-HT3A and 5-HT3AB receptor currents strongly. T

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